Behandlung von Opioidsucht - Eine Übersicht
Behandlung von Opioidsucht - Eine Übersicht
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Prescribers should always follow appropriate pain management principles of careful assessment and ongoing monitoring.
Take methadone hydrochloride tablets exactly as prescribed. Follow your doctor's directions exactly. Your doctor may change your dose based on your reactions to the medicine.
Stopping methadone hydrochloride tablets. Ask your doctor for instructions on how to stop this medicine slowly to avoid uncomfortable symptoms. You should not stop taking methadone hydrochloride tablets all at once if you have been taking it for more than a few days.
Methadone can be abused in a manner similar to other opioid agonists, legal or illicit. This should Beryllium considered when prescribing or dispensing methadone hydrochloride tablets hinein situations where the clinician is concerned about an increased risk of misuse, abuse, or diversion.
Switching a patient from another chronically administered opioid to methadone requires caution due to the uncertainty of dose conversion ratios and incomplete cross-tolerance. Deaths have occurred hinein opioid tolerant patients during conversion to methadone. Conversion ratios hinein many commonly used equianalgesic dosing tables do not apply hinein the Umgebung of repeated methadone dosing.
Methadone hydrochloride is a mu-agonist; a synthetic opioid analgesic with multiple actions qualitatively similar to those of morphine, the most von rang und namen of which involves the central nervous Organismus and organs composed of smooth muscle.
Read the Patient Information that comes with methadone hydrochloride tablets before you take it and each time you get a new prescription.
Hepatic Impairment – Methadone has not been extensively evaluated in patients Methadontabletten ohne Rezept online with hepatic insufficiency. Methadone is metabolized by hepatic pathways, therefore patients with liver impairment may Beryllium at risk of accumulating methadone after multiple dosing.
Methadone should be used with caution hinein elderly and debilitated patients; patients who are known to be sensitive to central nervous system depressants, such as those with cardiovascular, pulmonary, renal, or hepatic disease; and rein patients with comorbid conditions or concomitant medications which may predispose to dysrhythmia.
In vitro results suggest that methadone undergoes hepatic Nitrogenium-demethylation by cytochrome P450 enzymes, principally CYP3A4, CYP2B6, CYP2C19 and to a lesser extent by CYP2C9 and CYP2D6. Coadministration of methadone with CYP inducers of these enzymes may result hinein a more rapid metabolism and potential for decreased effects of methadone, whereas administration with CYP inhibitors may reduce metabolism and potentiate methadone's effects.
Methadone-maintained patients beginning treatment with CYP3A4 inducers should Beryllium monitored for evidence of withdrawal effects and methadone dose should be adjusted accordingly.
Cimetidine. Taking this drug with methadone may cause increased drowsiness and slowed breathing. Your doctor might adjust your dosage of methadone, depending on how severe your side effects are.
If you’ve had a recent head injury, it increases your risk of breathing problems from methadone. Talk to your doctor about whether this drug is safe for you.
Your kidneys may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays rein your body for a longer time. This raises your risk of side effects.